Entries by Amar Safdar

CHAPTER 50. Prophylactic Vaccination of Cancer Patients and Hematopoietic Stem Cell Transplant Recipients by William Decker and Amar Safdar

ABSTRACT Prophylactic immunization in cancer patients is safe and cost-effective in reducing the disease burden and complications arising from vaccine preventable infections. For maximal effectiveness, patients should be vaccinated with inactivated vaccines at least two weeks prior or three months subsequent to myeloablative chemotherapy.  Hematopoietic stem cell transplant recipients should similarly be vaccinated 6-12 months […]

CHAPTER 49. Prevention of Tropical and Parasitic Infections: The Immunocompromised traveler by Francesca F. Norman and Rogelio López-Vélez

ABSTRACT The number of immunocompromised travelers is increasing and persons with significant pre-existing medical conditions may be exposed to infectious diseases at their destination of choice. The risks of developing severe disease are increased and adivising these complex patients may be challenging for health care professionals. Recommendations for prevention of specific travel-related infections and vaccination […]

CHAPTER 48. Infection prevention – protected environment and infection control by J. Peter Donnelly

ABSTRACT In our daily life, we all encounter a range of microorganisms by breathing, eating and drinking and by direct contact with each other and the objects around us. This routine occasionally leads to infection. By contrast, patients who are given chemotherapy to treat cancer can succumb dramatically when confronted with these commonplace infections. Moreover […]

CHAPTER 47. Controversies in Antimicrobial Prophylaxis by Ben de Pauw and Marta Stanzani

ABSTRACT The risk of life threatening infection in association with chemotherapy induced neutropenia coincided miraculously with the development of a second generation of antimicrobial agents. Even after having randomized more than 10,000 patients in clinical trials on prophylaxis during neutropenia there is still no convincing scientific evidence to support the apparently attractive strategy. Even trials […]

CHAPTER 46. Antibacterial, Antifungal and Antiviral Prophylaxis in High-Risk Cancer and Stem Cell Transplant Population by Marcio Nucci and John R. Wingard

ABSTRACT Infection represents a major cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) recipients and cancer patients. Antimicrobial prophylaxis is justifiable in these immunosuppressed patients, but its benefits may be offset by potential problems such as the selection for resistant organisms, an increase in toxicity and cost. Therefore, any attempt to administer […]

CHAPTER 45. Prevention of Antimicrobial Resistance: Current and Future Strategies by Cesar A. Arias and Adolf W. Karchmer

ABSTRACT Antibiotic-resistant organisms are now commonly found in centers dedicated to the care of cancer patients, but most worrisome, have been increasingly reported as a cause of serious infections in community settings, even in healthy individuals with no apparent contacts with the health system. The discovery and development of antimicrobial agents is one of the […]

Chapter 44. Controversies in Antimicrobial Stewardship by Graeme N. Forrest

ABSTRACT Antimicrobial stewardship programs are recommended by the Infectious Diseases Society of America as a method to control antimicrobial costs and resistance. These programs are usually implemented hospital wide, but there is little evidence on their effects in oncology units. Three controversial areas of antimicrobial stewardship in oncology units include whether these programs decrease antimicrobial resistance […]

Chapter 43. Antimicrobial Stewardship: Considerations for a Cancer Center by Cora Mihu, Alla Paskovaty, Susan K. Seo

ABSTRACT Since the discovery of penicillin, unbridled enthusiasm for antibiotics has led to their extensive application in medicine, animal care, and agriculture. Injudicious antimicrobial use has also contributed to the emergence and spread of multidrug-resistant bacteria, creating a situation in which there are few or no treatment options for infections due to these organisms.  There […]

CHAPTER 42. Zoonoses in Cancer Patients by Donald Armstrong

ABSTRACT       Prevention of zoonoses in cancer patients is the theme of this chapter and it is hoped that it will encourage and help doctors caring for such patients to educate them to avoid the infections. Avoidance need not include seperation from a pet or occupation or recreation, but the use of caution […]

CHAPTER 41. Parasitic Infections in Cancer Patients: Toxoplasmosis, Strongyloidiasis, and Other Parasites by Brian G. Blackburn and José G. Montoya

ABSTRACT The most important parasitic infections in cancer patients are Toxoplasma gondii and Strongyloides stercoralis.  Both can cause life-threatening disease in immunocompromised patients, where T. gondii can present as encephalitis, pneumonia, fever of unknown origin, myocarditis, hepatitis, and chorioretinitis, and S. stercoralis as the disseminated hyperinfection syndrome.  Effective therapies are available for both, but high […]